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A mitochondrion targeting fluorescent probe for imaging of intracellular superoxide radicals

  • Author(s): Si, F
  • Liu, Y
  • Yan, K
  • Zhong, W
  • et al.
Abstract

© The Royal Society of Chemistry 2015. An amine-reactive fluorogenic molecule specifically turned on by superoxide radicals (O2•-) was synthesized and coupled to a mitochondrial (MT) targeting peptide. The obtained probe showed superior uptake and MT targeting capabilities; and successfully detected the change in O2•-levels in cells treated with chemical stimuli or single-walled carbon nanotubes.

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