Lawrence Berkeley National Laboratory
One-pot anti-Markovnikov hydroamination of unactivated alkenes by hydrozirconation and amination.
- Author(s): Strom, Alexandra E
- Hartwig, John F
- et al.
Published Web Locationhttps://doi.org/10.1021/jo401498w
A one-pot anti-Markovnikov hydroamination of alkenes is reported. The synthesis of primary and secondary amines from unactivated olefins was accomplished in the presence of a variety of functional groups. Hydrozirconation, followed by amination with nitrogen electrophiles, provides exclusive anti-Markovnikov selectivity. Most products are isolated in high yields without the use of column chromatography.