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One-pot anti-Markovnikov hydroamination of unactivated alkenes by hydrozirconation and amination.

  • Author(s): Strom, Alexandra E
  • Hartwig, John F
  • et al.

Published Web Location

https://doi.org/10.1021/jo401498w
Abstract

A one-pot anti-Markovnikov hydroamination of alkenes is reported. The synthesis of primary and secondary amines from unactivated olefins was accomplished in the presence of a variety of functional groups. Hydrozirconation, followed by amination with nitrogen electrophiles, provides exclusive anti-Markovnikov selectivity. Most products are isolated in high yields without the use of column chromatography.

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