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Blockade of Specific NOTCH Ligands: A New Promising Approach in Cancer Therapy

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342039/
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Abstract

Summary

The signaling specificity conveyed by distinct combination of NOTCH receptors/ligands has remained elusive. In this issue of Cancer Discovery, through the development of ligand-specific NOTCH inhibitors, Kangsamaksin and colleagues uncovered unique signaling outcomes downstream of DLL- and JAG-receptor activation and demonstrated their effects in the suppression of tumor angiogenesis.

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