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Topographical Distribution of Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex.

  • Author(s): Ellingson, Benjamin M
  • Hirata, Yoko
  • Yogi, Akira
  • Karavaeva, Elena
  • Leu, Kevin
  • Woodworth, Davis C
  • Harris, Robert J
  • Enzmann, Dieter R
  • Wu, Joyce Y
  • Mathern, Gary W
  • Salamon, Noriko
  • et al.
Abstract

Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the inferior parietal lobe and within the central sulcus region in children younger than 1 or between 1 and 3 years old, respectively. Results imply seizure activity in tuberous sclerosis complex patients can be associated with the location of cortical tubers.

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