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Asymmetric gold-catalyzed lactonizations in water at room temperature

  • Author(s): Handa, S
  • Lippincott, DJ
  • Aue, DH
  • Lipshutz, BH
  • et al.

Published Web Location

http://10.0.3.234/anie.201404729
No data is associated with this publication.
Abstract

Asymmetric gold-catalyzed hydrocarboxylations are reported that show broad substrate scope. The hydrophobic effect associated with in situ-formed aqueous nanomicelles gives good to excellent ee's of product lactones. In-flask product isolation, along with the recycling of the catalyst and the reaction medium, are combined to arrive at an especially environmentally friendly process. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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