UC Santa Barbara
Asymmetric gold-catalyzed lactonizations in water at room temperature
- Author(s): Handa, S
- Lippincott, DJ
- Aue, DH
- Lipshutz, BH
- et al.
Published Web Locationhttp://10.0.3.234/anie.201404729
Asymmetric gold-catalyzed hydrocarboxylations are reported that show broad substrate scope. The hydrophobic effect associated with in situ-formed aqueous nanomicelles gives good to excellent ee's of product lactones. In-flask product isolation, along with the recycling of the catalyst and the reaction medium, are combined to arrive at an especially environmentally friendly process. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.