UC Berkeley

Air pollution is a serious environmental problem in China. Birth defects are particularly vulnerable to outdoor air pollution. Our study was to evaluate the association between short-term exposure to air pollutants and the risk of birth defects. Daily data including the air pollutants, meteorological characteristics, and birth records were obtained in Hefei, China, during January 2013 to December 2016. The findings showed that PM_2.5, PM₁₀, SO₂, NO₂, and O₃ exposures were positively correlated with the risk of birth defects. Maternal exposure to PM_2.5 and SO₂ during the 4th to 13th gestational weeks was observed to have a significant association with the risk of birth defects, with the maximum effect in the 7th or 8th week for PM_2.5 and the maximum effect in the 7th week for SO₂. The positively significant exposure windows were the 4th to 14th weeks for PM₁₀, the 4th to 12th weeks for NO₂, and the 26th to 35th weeks for O₃, respectively. The strongest associations were observed in the 8th week for PM₁₀, the 7th week for NO₂, and in the 31st or 32nd week for O_3. The findings of this study demonstrate that air pollutants increase the risk of birth defects among women during pregnancy in Hefei, China, which provide evidence for improving the health of pregnant women and neonates in developing countries, and uncovered potential opportunities to reduce or prevent birth defects by proactive measures during pregnancy.