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Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis
- Sallam, Tamer;
- Jones, Marius C;
- Gilliland, Thomas;
- Zhang, Li;
- Wu, Xiaohui;
- Eskin, Ascia;
- Sandhu, Jaspreet;
- Casero, David;
- Vallim, Thomas Q de Aguiar;
- Hong, Cynthia;
- Katz, Melanie;
- Lee, Richard;
- Whitelegge, Julian;
- Tontonoz, Peter
Published Web Location
https://doi.org/10.1038/nature17674Abstract
The activation of lipid X receptors (LXRs) in mouse liver not only promotes cholesterol efflux but also inhibits cholesterol synthesis simultaneously; this is mediated by the lipid-responsive long non-coding RNA LeXis, which is induced by a Western diet and orchestrates crosstalk between LXRs and the cholesterol biosynthetic pathway.
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