Skip to main content
eScholarship
Open Access Publications from the University of California

Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid

  • Author(s): Yang, X
  • Toste, FD
  • et al.

Published Web Location

http://doi.org/10.1039/c5sc04202j
No data is associated with this publication.
Abstract

© The Royal Society of Chemistry 2016. We describe the asymmetric addition of unactivated α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid, generating an all-carbon quaternary stereocenter with broad substrate scope and high enantioselectivity. The products are easily transformed into their corresponding 1,5- and 1,4-ketoaldehyde derivatives, which are both important building blocks in organic synthesis.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item