Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid
- Author(s): Yang, X
- Toste, FD
- et al.
Published Web Locationhttp://doi.org/10.1039/c5sc04202j
© The Royal Society of Chemistry 2016. We describe the asymmetric addition of unactivated α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid, generating an all-carbon quaternary stereocenter with broad substrate scope and high enantioselectivity. The products are easily transformed into their corresponding 1,5- and 1,4-ketoaldehyde derivatives, which are both important building blocks in organic synthesis.
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