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β-cell mass and turnover in humans: effects of obesity and aging.

  • Author(s): Saisho, Yoshifumi
  • Butler, Alexandra E
  • Manesso, Erica
  • Elashoff, David
  • Rizza, Robert A
  • Butler, Peter C
  • et al.

Published Web Location

https://doi.org/10.2337/dc12-0421
Abstract

Objective

We sought to establish β-cell mass, β-cell apoptosis, and β-cell replication in humans in response to obesity and advanced age.

Research design and methods

We examined human autopsy pancreas from 167 nondiabetic individuals 20-102 years of age. The effect of obesity on β-cell mass was examined in 53 lean and 61 obese subjects, and the effect of aging was examined in 106 lean subjects.

Results

β-Cell mass is increased by ~50% with obesity (from 0.8 to 1.2 g). With advanced aging, the exocrine pancreas undergoes atrophy but β-cell mass is remarkably preserved. There is minimal β-cell replication or apoptosis in lean humans throughout life with no detectable changes with obesity or advanced age.

Conclusions

β-Cell mass in human obesity increases by ~50% by an increase in β-cell number, the source of which is unknown. β-Cell mass is well preserved in humans with advanced aging.

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