Exploring histidine conformations in the M2 channel lumen of the influenza a virus at neutral pH via molecular simulations
- Author(s): Degrado, William
- Dong, H
- Fiorin, G
- Degrado, WF
- Klein, ML
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3779100?pdf=render
The pH-regulated M2 proton channel from the influenza A virus has a His-tetrad in its transmembrane (TM) domain that is essential for proton conduction. At neutral pH, the tetrad has been observed in two distinct configurations, the "His-box" and "dimer-of
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