Skip to main content
eScholarship
Open Access Publications from the University of California
Refine Search

UC Irvine

UC Irvine Previously Published Works bannerUC Irvine

Structural Insights into the Activation of mTORC1 on the Lysosomal Surface

Published Web Location

https://doi.org/10.1016/j.tibs.2020.02.004
Abstract

Using cryo-electron microscopy and molecular characterization, David Sabatini and colleagues provide crucial new insights that validate and expand their model of how amino acids are sensed and signal at the lysosome to activate mechanistic target of rapamycin complex 1 (mTORC1) and cell growth-regulating processes. This work also reveals new therapeutic opportunities for mTORC1-driven diseases.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View


Top