Skip to main content
eScholarship
Open Access Publications from the University of California

UCSF

UC San Francisco Previously Published Works bannerUCSF

Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility.

  • Author(s): Yu, Jai Y
  • Kay, Kenneth
  • Liu, Daniel F
  • Grossrubatscher, Irene
  • Loback, Adrianna
  • Sosa, Marielena
  • Chung, Jason E
  • Karlsson, Mattias P
  • Larkin, Margaret C
  • Frank, Loren M
  • et al.

Published Web Location

https://elifesciences.org/articles/27621
No data is associated with this publication.
Abstract

While ongoing experience proceeds continuously, memories of past experience are often recalled as episodes with defined beginnings and ends. The neural mechanisms that lead to the formation of discrete episodes from the stream of neural activity patterns representing ongoing experience are unknown. To investigate these mechanisms, we recorded neural activity in the rat hippocampus and prefrontal cortex, structures critical for memory processes. We show that during spatial navigation, hippocampal CA1 place cells maintain a continuous spatial representation across different states of motion (movement and immobility). In contrast, during sharp-wave ripples (SWRs), when representations of experience are transiently reactivated from memory, movement- and immobility-associated activity patterns are most often reactivated separately. Concurrently, distinct hippocampal reactivations of movement- or immobility-associated representations are accompanied by distinct modulation patterns in prefrontal cortex. These findings demonstrate a continuous representation of ongoing experience can be separated into independently reactivated memory representations.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item