Skip to main content
eScholarship
Open Access Publications from the University of California

Seizure-induced basal dendrites on granule cells

  • Author(s): Ribak, Charles E
  • Shapiro, Lee A
  • Yan, Xiao-Xin
  • Dashtipour, Khashayar
  • Nadler, J Victor
  • Obenaus, Andre
  • Spigelman, Igor
  • Buckmaster, Paul S
  • et al.
Abstract

Seizure-induced hilar basal dendrites on dentate granule cells are observed in several rodent models of temporal lobe epilepsy. Ultrastructural evidence showed that basal dendrites receive predominantly excitatory synapses, including many from mossy fibers. Such highly interconnected granule cells with basal dendrites are suggested to enhance hyperexcitability within the dentate network. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at). © 2010 International League Against Epilepsy.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View