Genetic advances uncover mechanisms of chemotherapy-induced peripheral neuropathy.
- Author(s): Chua, KC
- Kroetz, DL
- et al.
Published Web Locationhttps://doi.org/10.1002/cpt.590
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity experienced in 30-40% of patients undergoing treatment with various chemotherapeutics, including taxanes, vinca alkaloids, epothilones, proteasome inhibitors, and thalidomide. Importantly, CIPN significantly affects a patient's quality of life. Recent genetic association studies are enhancing our understanding of CIPN pathophysiology and serve as a foundation for identification of genetic biomarkers to predict toxicity risk and for the development of novel strategies for prevention and treatment.