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Open Access Publications from the University of California

Novel codon insert in HIV type 1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy.

  • Author(s): Chaillon, Antoine
  • Gianella, Sara
  • Vazquez, Homero
  • Ignacio, Caroline
  • Zweig, Adam C
  • Richman, Douglas D
  • Smith, Davey M
  • et al.

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We investigated the pol genotype in two phylogenetically and epidemiologically linked partners, who were both experiencing persistent low-level viremia during antiretroviral therapy. In one partner we identified a new residue insertion between codon 248 and 249 of the HIV-1 RNA reverse transcriptase (RT) coding region (HXB2 numbering). We then investigated the potential impact of identified mutations in RT and antiretroviral binding affinity using a novel computational approach.

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