Research Grants Program Office (RGPO)
Novel codon insert in HIV type 1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy.
- Author(s): Chaillon, Antoine
- Gianella, Sara
- Vazquez, Homero
- Ignacio, Caroline
- Zweig, Adam C
- Richman, Douglas D
- Smith, Davey M
- et al.
Published Web Locationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910474/
We investigated the pol genotype in two phylogenetically and epidemiologically linked partners, who were both experiencing persistent low-level viremia during antiretroviral therapy. In one partner we identified a new residue insertion between codon 248 and 249 of the HIV-1 RNA reverse transcriptase (RT) coding region (HXB2 numbering). We then investigated the potential impact of identified mutations in RT and antiretroviral binding affinity using a novel computational approach.