A new precursor for the preparation of 6-[18F]-fluoro-L-m-tyrosine (FMT): Efficient
synthesis and comparison of radiolabeling
- Author(s): VanBrocklin, Henry F.
- Blagoev, Milan
- Hoepping, Alexander
- O'Neil, James P.
- Klose, Manuela
- Schubiger, Pius A.
- Ametamey, Simon
- et al.
For the electrophilic preparation of 6-[18F]-Fluoro-L-m-tyrosine (FMT), a PET tracer for measuring changes in dopaminergic function in movement disorders, a novel precursor, N-(tert-butoxycarbonyl)-3-(tert-butoxycarbonyloxy)-6-trimethylstannnyl-L-phenylalanine ethyl ester, was synthesized in four steps and 26 percent yield starting from L-m-tyrosine. FMT produced by two methods at two institutions was comparable in decay corrected yield, 25-26 percent, and quality (chemical, enantiomeric, and radiochemical purity and specific activity) as that obtained with the original N-trifluoroacetyl-3-acetyl-6-trimethylstannyl-L-m-tyrosine ethyl ester FMT precursor.