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Synthesis of Hindered α‑Amino Carbonyls: Copper-Catalyzed Radical Addition with Nitroso Compounds

Published Web Location

https://doi.org/10.1021/jacs.5b07860
Abstract

The synthesis of sterically hindered anilines has been a significant challenge in organic chemistry. Here we report a Cu-catalyzed radical addition with in situ-generated nitroso compounds to prepare sterically hindered amines directly from readily available materials. The transformation is conducted at room temperature, uses abundant copper salts, and is tolerant of a range of functional groups.

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