UC San Diego

This is a summary of the research of Charles L. Perrin and his coworkers in the areas of aromatic mercuration, vibronic borrowing, ipso factors in electrophilic aromatic substitution, malonic anhydrides, mechanisms of proton exchange in amides, stereoelectronic control, the so-called reverse anomeric effect, an NMR titration method for highly accurate measurement of relative acidities, secondary deuterium isotope effects on acidity, symmetry of hydrogen bonds in solution, and nucleophilic addition to a para-benzyne diradical, along with Perrin's contributions to teaching and to service. © 2014 John Wiley & Sons, Ltd.