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Open Access Publications from the University of California

Synthesis and Characterization of Fluorescence Lifetime Probe Library constructed using Quantum dots and Organic dyes in a Multicomponent Silica shell

  • Author(s): Kainkaryam, Ashwin Melkote
  • Advisor(s): Haun, Jered B
  • et al.
Abstract

In the recent years, significant emphasis is dedicated towards the application of nanomaterials for targeted deliveries. Using the diverse optic properties of quantum dots and fluorescent dyes and the versatile advantages of silica shell such as being biocompatible, their ease of synthesis and their drug loading platforms, they are used in biomedical and biological applications. This project explains the synthesis and characterization of multiplexed nanoprobes which are used for cancer detection studies. The nanoprobes were synthesized with various sizes and aspect ratios, involving various fluorescent dyes with a wide range of lifetime., and with varied loading concentrations of dyes and quantum dots as cores to sandwiching dyes between a shell and a core.

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