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Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19.

  • Author(s): Dudoignon, Emmanuel;
  • Moreno, Nabila;
  • Deniau, Benjamin;
  • Coutrot, Maxime;
  • Longer, Romain;
  • Amiot, Quentin;
  • Mebazaa, Alexandre;
  • Pirracchio, Romain;
  • Depret, François;
  • Legrand, Matthieu
  • et al.
Abstract

The pathophysiology of acute kidney injury (AKI) in COVID-19 patients is still poorly understood. SARS-CoV-2 has been suggested to modulate the renin-angiotensin-aldosterone system (RAAS). In this series of COVID-19 critically ill patients, we report evidence of activation of the RAAS in COVID-19 patients with AKI.

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