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Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.

  • Author(s): Dan, Jennifer M
  • Mateus, Jose
  • Kato, Yu
  • Hastie, Kathryn M
  • Yu, Esther Dawen
  • Faliti, Caterina E
  • Grifoni, Alba
  • Ramirez, Sydney I
  • Haupt, Sonya
  • Frazier, April
  • Nakao, Catherine
  • Rayaprolu, Vamseedhar
  • Rawlings, Stephen A
  • Peters, Bjoern
  • Krammer, Florian
  • Simon, Viviana
  • Saphire, Erica Ollmann
  • Smith, Davey M
  • Weiskopf, Daniela
  • Sette, Alessandro
  • Crotty, Shane
  • et al.

Published Web Location

https://science.sciencemag.org/content/early/2021/01/06/science.abf4063
No data is associated with this publication.
Abstract

Understanding immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics and vaccines and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥6 months after infection. Immunoglobulin G (IgG) to the spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month after symptom onset. SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3 to 5 months. By studying antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.

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