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Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies.

  • Author(s): Dunlap, Lee E;
  • Azinfar, Arya;
  • Ly, Calvin;
  • Cameron, Lindsay P;
  • Viswanathan, Jayashri;
  • Tombari, Robert J;
  • Myers-Turnbull, Douglas;
  • Taylor, Jack C;
  • Grodzki, Ana Cristina;
  • Lein, Pamela J;
  • Kokel, David;
  • Olson, David E
  • et al.
Abstract

Ketamine, N,N-dimethyltryptamine (DMT), and other psychoplastogens possess enormous potential as neurotherapeutics due to their ability to potently promote neuronal growth. Here, we report the first-ever structure-activity relationship study with the explicit goal of identifying novel psychoplastogens. We have discovered several key features of the psychoplastogenic pharmacophore and used this information to develop N,N-dimethylaminoisotryptamine (isoDMT) psychoplastogens that are easier to synthesize, have improved physicochemical properties, and possess reduced hallucinogenic potential as compared to their DMT counterparts.

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