Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2.
- Author(s): Földy, Csaba
- Lee, Sang-Hun
- Morgan, Robert J
- Soltesz, Ivan
- et al.
Published Web Locationhttps://doi.org/10.1038/nn.2609
Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.