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Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2.

  • Author(s): Földy, Csaba
  • Lee, Sang-Hun
  • Morgan, Robert J
  • Soltesz, Ivan
  • et al.

Published Web Location

https://doi.org/10.1038/nn.2609
Abstract

Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

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