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Plasma Cell-Free DNA Next-Generation Sequencing to Diagnose and Monitor Infections in Allogeneic Hematopoietic Stem Cell Transplant Patients.

  • Author(s): Fung, Monica
  • Zompi, Simona
  • Seng, Hon
  • Hollemon, Desiree
  • Parham, Adama
  • Hong, David K
  • Bercovici, Sivan
  • Dolan, Estelle
  • Lien, Kathy
  • Teraoka, Justin
  • Logan, Aaron C
  • Chin-Hong, Peter
  • et al.
Abstract

Allogeneic hematopoietic stem cell transplant patients are at risk for common and atypical infections. Superior diagnostics can decrease infection-related morbidity and mortality. A novel plasma cell-free DNA next-generation sequencing test detected an uncommon presentation of Chlamydia trachomatis and recurrent and metastatic complications of Staphylococcus aureus bacteremia before standard microbiology.

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