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Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis
- Miller, Matthew S;
- Rialdi, Alexander;
- Ho, Jessica Sook Yuin;
- Tilove, Micah;
- Martinez-Gil, Luis;
- Moshkina, Natasha P;
- Peralta, Zuleyma;
- Noel, Justine;
- Melegari, Camilla;
- Maestre, Ana M;
- Mitsopoulos, Panagiotis;
- Madrenas, Joaquín;
- Heinz, Sven;
- Benner, Chris;
- Young, John AT;
- Feagins, Alicia R;
- Basler, Christopher F;
- Fernandez-Sesma, Ana;
- Becherel, Olivier J;
- Lavin, Martin F;
- van Bakel, Harm;
- Marazzi, Ivan
Published Web Location
https://doi.org/10.1038/ni.3132Abstract
Mutations in the gene encoding the helicase senataxin have well established associations with the neurodegenerative disease ALS. Marazzi et al. show that senataxin can also attenuate virus-triggered responses by controlling RNA polymerase activity at genes encoding antiviral molecules.
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