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Landscape and variation of RNA secondary structure across the human transcriptome
Published Web Location
https://doi.org/10.1038/nature12946Abstract
An RNA secondary structure (RSS) map of coding and noncoding RNA from a human family (two parents and their child) is produced; this reveals that approximately 15% of all transcribed single nucleotide variants (SNVs) alter local RNA structure, and these SNVs are depleted in certain locations, suggesting that particular RNA structures are important at those sites.
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