UCLA

Microfluidic applications often face challenges such as the necessity for costly cleanrooms, limited to single-level designs, and labor-intensive preparation processes that are prone to errors. These constraints significantly hinder the capabilities of laboratories that require cost-effective methods for conducting research with microfluidic devices. Fortunately, the emerging capabilities of 3D printing technology, particularly its improving resolution, offer a promising solution to these issues. 3D printing allows for a less laborious, more scalable approach to crafting complex, multi-level microfluidic devices. However, developing an effective droplet generator comes with its own set of challenges such as achieving precise control over droplet size, ensuring uniform droplet production, and managing fluid dynamics within complex microfluidic networks. This thesis addresses these challenges by introducing a novel method for producing drug-laden microparticles using a high-throughput, branched, multi-level droplet generator, all implemented using a commercially available 3D printer alongside freely accessible CAD and slicer software. This advancement enables researchers to swiftly share and create innovative designs, significantly reducing both time and cost in the production process.