Skip to main content
Download PDF
- Main
Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy
- Shalapour, Shabnam;
- Font-Burgada, Joan;
- Di Caro, Giuseppe;
- Zhong, Zhenyu;
- Sanchez-Lopez, Elsa;
- Dhar, Debanjan;
- Willimsky, Gerald;
- Ammirante, Massimo;
- Strasner, Amy;
- Hansel, Donna E;
- Jamieson, Christina;
- Kane, Christopher J;
- Klatte, Tobias;
- Birner, Peter;
- Kenner, Lukas;
- Karin, Michael
Published Web Location
https://doi.org/10.1038/nature14395Abstract
IgA plasmocytes are shown to promote resistance to the immunogenic chemotherapeutic oxaliplatin in prostate cancer mouse models by inhibiting activation of cytotoxic T cells; immunosuppressive plasma cells, which are also found in human-therapy-resistant prostate cancer, are generated in response to TGFβ, and their functionality depends on PD-L1 expression and IL-10 secretion.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.