Skip to main content
Open Access Publications from the University of California

UC Irvine

UC Irvine Previously Published Works bannerUC Irvine

Evaluation of safety of increased time interval between chemoradiation and resection for rectal cancer

  • Author(s): Tran, C L;
  • Udani, S;
  • Holt, A;
  • Arnell, T;
  • Kumar, R;
  • Stamos, Michael J
  • et al.

Background: Neoadjuvant chemoradiation is increasingly used for rectal cancer, with resection typically performed 6 weeks after completion of radiotherapy. We observed in our practice that further delay after radiotherapy led to increased downsizing. We performed this retrospective analysis to evaluate the safety of this approach. Methods: A retrospective review was performed of 48 patients with distal or mid-rectal cancer who were operated on 8 weeks or less after chemoradiation ended (group 1, n = 16), and more than 8 weeks later (group 2, n = 32). We looked at the effect of delaying surgery on intraoperative blood loss, operative and hospital duration, postoperative complications, readmissions, and mortality. Results: The median interval between radiation and operation was 7 weeks in group 1 and 11 weeks in group 2. There was no significant difference between the 2 groups in terms of intraoperative blood loss, postoperative complications, or readmissions. Length of operation and length of stay were slightly longer for group 2. Conclusions: Delaying surgery after neoadjuvant treatment appears safe, with morbidity and mortality similar to that seen with Surgery performed less than 8 weeks after chemoradiation. (c) 2006 Excerpta Medica Inc. All rights reserved.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View