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Sex differences in gout characteristics: tailoring care for women and men.

  • Author(s): Harrold, Leslie R
  • Etzel, Carol J
  • Gibofsky, Allan
  • Kremer, Joel M
  • Pillinger, Michael H
  • Saag, Kenneth G
  • Schlesinger, Naomi
  • Terkeltaub, Robert
  • Cox, Vanessa
  • Greenberg, Jeffrey D
  • et al.


To characterize the differences between women and men with gout.


We analyzed a US national cohort of gout patients cared for by rheumatologists.


Compared with the 1012 men with gout, women with gout (n = 262) were older (71 vs. 61 years, p < 0.001) and had a greater burden of comorbid conditions (p < 0.001 for hypertension, diabetes, renal disease and obesity). Risk factors for gout differed with women more often taking diuretics (p < 0.001), while men more frequently had dietary triggers (p < 0.05).


The profiles of women and men with gout are markedly different, suggesting a need to tailor treatment recommendations.

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