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Open Access Publications from the University of California

VISTA tools for interactive visualization and analysis of multiple alignments of DNA sequences and whole genomes

  • Author(s): Shah, Nameeta
  • Poliakov, Alexander
  • Ryaboy, Dmitriy
  • Teplitsky, Michael V.
  • Hamann, Bernd
  • Rubin, Edward M.
  • Dubchak, Inna L.
  • et al.

Recent studies in the field of comparative genomics demonstrate that multi-species DNA comparison presents a powerful method for discovering functional genomic sequences. Similarity across large evolutionary distances usually reveals conserved, and, by inference, important biological features. Expanding the capabilities of computational tools designed for pair wise DNA comparisons to multiple species requires the development of new algorithms for alignment, analysis of conservation, and visualization of results.

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