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Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021
- Lewis, Nathaniel M;
- Naioti, Eric A;
- Self, Wesley H;
- Ginde, Adit A;
- Douin, David J;
- Talbot, H Keipp;
- Casey, Jonathan D;
- Mohr, Nicholas M;
- Zepeski, Anne;
- Gaglani, Manjusha;
- Ghamande, Shekhar A;
- McNeal, Tresa A;
- Shapiro, Nathan I;
- Gibbs, Kevin W;
- Files, D Clark;
- Hager, David N;
- Shehu, Arber;
- Prekker, Matthew E;
- Erickson, Heidi L;
- Gong, Michelle N;
- Mohamed, Amira;
- Henning, Daniel J;
- Steingrub, Jay S;
- Peltan, Ithan D;
- Brown, Samuel M;
- Martin, Emily T;
- Hubel, Kinsley;
- Hough, Catherine L;
- Busse, Laurence W;
- Lohuis, Caitlin C ten;
- Duggal, Abhijit;
- Wilson, Jennifer G;
- Gordon, Alexandra J;
- Qadir, Nida;
- Chang, Steven Y;
- Mallow, Christopher;
- Rivas, Carolina;
- Babcock, Hilary M;
- Kwon, Jennie H;
- Exline, Matthew C;
- Halasa, Natasha;
- Chappell, James D;
- Lauring, Adam S;
- Grijalva, Carlos G;
- Rice, Todd W;
- Rhoads, Jillian P;
- Stubblefield, William B;
- Baughman, Adrienne;
- Womack, Kelsey N;
- Lindsell, Christopher J;
- Hart, Kimberly W;
- Zhu, Yuwei;
- Schrag, Stephanie J;
- Kobayashi, Miwako;
- Verani, Jennifer R;
- Patel, Manish M;
- Tenforde, Mark W;
- Collaborators, IVY Network;
- McNeal, Tresa;
- Ghamande, Shekhar;
- Calhoun, Nicole;
- Murthy, Kempapura;
- Herrick, Judy;
- McKillop, Amanda;
- Hoffman, Eric;
- Zayed, Martha;
- Smith, Michael;
- Settele, Natalie;
- Ettlinger, Jason;
- Priest, Elisa;
- Thomas, Jennifer;
- Arroliga, Alejandro;
- Beeram, Madhava;
- Kindle, Ryan;
- Kozikowski, Lori-Ann;
- De Souza, Lesley;
- Ouellette, Scott;
- Thornton-Thompson, Sherell;
- Tyler, Patrick;
- Mehkri, Omar;
- Mitchell, Meg;
- Brennan, Connery;
- Ashok, Kiran;
- Poynter, Bryan;
- Stanley, Nicholas;
- Hendrickson, Audrey;
- Caspers, Sean;
- Scharber, Tyler;
- Jorgensen, Jeffrey;
- Bowers, Robert;
- King, Jennifer;
- Aston, Valerie;
- Armbruster, Brent;
- Rothman, Richard E;
- Nair, Rahul;
- Chen, Jen-Ting;
- Karow, Sarah;
- Robart, Emily;
- Maldonado, Paulo Nunes;
- Khan, Maryiam;
- So, Preston;
- Levitt, Joe;
- Perez, Cynthia;
- Visweswaran, Anita;
- Roque, Jonasel;
- Frankel, Trevor;
- Garner, Omai;
- Chandrasekaran, Sukantha;
- Goff, Jennifer;
- Huynh, David;
- Ginder, Adit;
- Douin, David;
- Jensen, Kelly;
- Driver, Conner;
- Carricato, Michael;
- Chambers, Ian;
- Nassar, Paul;
- Stout, Lori;
- Sibenaller, Zita;
- Walter, Alicia;
- Mares, Jasmine;
- Olson, Logan;
- Clinansmith, Bradley;
- Gershengorn, Hayley;
- McSpadden, EJ;
- Truscon, Rachel;
- Kaniclides, Anne;
- Thomas, Lara;
- Bielak, Ramsay;
- Valvano, Weronika Damek;
- Fong, Rebecca;
- Fitzsimmons, William J;
- Blair, Christopher;
- Valesano, Andrew L;
- Gilbert, Julie;
- Khan, Akram;
- Krol, Olivia;
- Zouyed, Zachary;
- Silverman, Emma;
- Briceno, Genesis;
- Mills, Emmanuel;
- Crider, Christine D;
- Steinbock, Kyle A;
- Paulson, Thomas C;
- Anderson, Layla A;
- Kampe, Christy;
- Johnson, Jakea;
- McHenry, Rendie;
- Blair, Marcia;
- Short, Laura;
- LaRose, Mary;
- Landreth, Leigha;
- Hicks, Madeline;
- Parks, Lisa;
- Bongu, Jahnavi;
- McDonald, David;
- Cass, Candice;
- Seiler, Sondra;
- Park, David;
- Hink, Tiffany;
- Wallace, Meghan;
- Burnham, Carey-Ann;
- Arter, Olivia G
- et al.
Published Web Location
https://doi.org/10.1093/infdis/jiab619Abstract
Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P > .05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.
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