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Open Access Publications from the University of California

Transition of a microRNA from Repressing to Activating Translation Depending on the Extent of Base Pairing with the Target

  • Author(s): Wang, Ching
  • Saraiya, AA
  • Li, W
  • Wang, CC
  • et al.

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MicroRNAs are major post-transcriptional regulators of gene expression. Here we show in the ancient protozoan Giardia lamblia a snoRNA-derived 26-nucleotide microRNA, miR3, which represses the translation of histone H2A mRNA containing an imperfect target

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