Transition of a microRNA from Repressing to Activating Translation Depending on the Extent of Base Pairing with the Target
- Author(s): Wang, Ching
- Saraiya, AA
- Li, W
- Wang, CC
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3565978?pdf=render
MicroRNAs are major post-transcriptional regulators of gene expression. Here we show in the ancient protozoan Giardia lamblia a snoRNA-derived 26-nucleotide microRNA, miR3, which represses the translation of histone H2A mRNA containing an imperfect target
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