RegTransBase - A Database Of Regulatory Sequences and Interactions in a Wide Range of Prokaryotic Genomes
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RegTransBase - A Database Of Regulatory Sequences and Interactions in a Wide Range of Prokaryotic Genomes

  • Author(s): Kazakov, Alexei E.
  • Cipriano, Michael J.
  • Novichkov, Pavel S.
  • Minovitsky, Simon
  • Vinogradov, Dmitry V.
  • Arkin, Adam
  • Mironov, Andrey A.
  • Gelfand, Mikhail S.
  • Dubchak, Inna
  • et al.
Abstract

RegTransBase, a manually curated database of regulatory interactions in prokaryotes, captures the knowledge in published scientific literature using a controlled vocabulary. Although a number of databases describing interactions between regulatory proteins and their binding sites are currently being maintained, they focus mostly on the model organisms Escherichia coli and Bacillus subtilis, or are entirely computationally derived. RegTransBase describes a large number of regulatory interactions reported in many organisms and contains various types of experimental data, in particular: the activation or repression of transcription by an identified direct regulator; determining the transcriptional regulatory function of a protein (or RNA) directly binding to DNA (RNA); mapping or prediction of binding site for a regulatory protein; characterization of regulatory mutations. Currently, the RegTransBase content is derived from about 3000 relevant articles describing over 7000 experiments in relation to 128 microbes. It contains data on the regulation of about 7500 genes and evidence for 6500 interactions with 650 regulators. RegTransBase also contains manually created position weight matrices (PWM) that can be used to identify candidate regulatory sites in over 60 species. RegTransBase is available at http://regtransbase.lbl.gov.

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