Skip to main content
Download PDF
- Main
Continued Slow Decay of the Residual Plasma Viremia Level in HIV-1–Infected Adults Receiving Long-term Antiretroviral Therapy
- Riddler, Sharon A;
- Aga, Evgenia;
- Bosch, Ronald J;
- Bastow, Barbara;
- Bedison, Margaret;
- Vagratian, David;
- Vaida, Florin;
- Eron, Joseph J;
- Gandhi, Rajesh T;
- Mellors, John W;
- Team, for the ACTG A5276s Protocol;
- Mirand, Amy;
- Klebert, Michael;
- Fry, Carrie;
- Dragavon, Joan;
- Koletar, Susan;
- Hite, Mark;
- Meixner, Linda;
- Seefried, Edward;
- Bagur, Jorge L Santana;
- Perez, Sigrid;
- Funk, Connie;
- Santos, Bartolo;
- Bailey, Vicki;
- Jackson, Brenda;
- Feinberg, Judith;
- Saemann, Michelle;
- Lindsey, Elizabeth;
- James, Tamara;
- Kronk, Catherine;
- Oakes, Jonathan;
- Adams, Mary;
- Hurley, Christine;
- Dunaway, Shelia;
- Storey, Sheryl S;
- Van Dam, Cornelius;
- Epperson, Kim;
- Tebas, Pablo;
- Thomas, Aleshia;
- Klevens, Lisa;
- Mattiucci, Sara;
- Walton, Trisha;
- Baum, Jane;
- Spitz, Teresa;
- DeMarco, Debra;
- Sha, Beverly E;
- Green, Tondria;
- Basler, Cathi;
- Griesmer, Christine;
- Aberg, Judith A;
- Cespedes, Michelle S;
- Valle, Sandra;
- Slamowitz, Debbie;
- Currier, Judith;
- Cajahuaringa, Vanessa;
- Taiwo, Babafemi;
- McGregor, Donna;
- Kumar, Princy;
- Timpone, Joseph;
- Albrecht, Mary;
- Kershaw, Andrea;
- Sax, Paul;
- Keenan, Cheryl;
- Daar, Eric;
- Lopez, Ruben;
- Luetkemeyer, Annie;
- Dwyer, Jay;
- Ellner, Jerrold;
- Linas, Benjamin;
- Hughes, Valery;
- Lopez-Detres, Luis;
- Davis, Traci;
- Whitely, Kim;
- Palmore, Melody;
- Gunthel, Clifford
- et al.
Published Web Location
https://doi.org/10.1093/infdis/jiv433Abstract
Unlabelled
We measured plasma human immunodeficiency virus type 1 (HIV-1) RNA levels by means of single-copy assay in 334 participants receiving virologically suppressive antiretroviral therapy (ART). A residual viremia load of ≥1 copy/mL after 4 years of ART was predicted by a higher pre-ART HIV-1 RNA level, higher CD8(+) T-cell count during treatment, and a lower ratio of CD4+ T cells to CD8+ T cells during treatment but not by initial ART regimen. In a longitudinal subset of 64 individuals, continued decay of the plasma HIV-1 RNA level was observed, with an average annual decrease of 6% and an estimated half-life of 11.5 years. In contrast to prior reports, the persistent viremia level continues to slowly decline during years 4-12 of suppressive ART.Clinical trials registration
NCT00001137.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
For improved accessibility of PDF content, download the file to your device.
Enter the password to open this PDF file:
File name:
-
File size:
-
Title:
-
Author:
-
Subject:
-
Keywords:
-
Creation Date:
-
Modification Date:
-
Creator:
-
PDF Producer:
-
PDF Version:
-
Page Count:
-
Page Size:
-
Fast Web View:
-
Preparing document for printing…
0%