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Continued Slow Decay of the Residual Plasma Viremia Level in HIV-1–Infected Adults Receiving Long-term Antiretroviral Therapy
- Riddler, Sharon A;
- Aga, Evgenia;
- Bosch, Ronald J;
- Bastow, Barbara;
- Bedison, Margaret;
- Vagratian, David;
- Vaida, Florin;
- Eron, Joseph J;
- Gandhi, Rajesh T;
- Mellors, John W;
- Mirand, Amy;
- Klebert, Michael;
- Fry, Carrie;
- Dragavon, Joan;
- Koletar, Susan;
- Hite, Mark;
- Meixner, Linda;
- Seefried, Edward;
- Bagur, Jorge L Santana;
- Perez, Sigrid;
- Funk, Connie;
- Santos, Bartolo;
- Bailey, Vicki;
- Jackson, Brenda;
- Feinberg, Judith;
- Saemann, Michelle;
- Lindsey, Elizabeth;
- James, Tamara;
- Kronk, Catherine;
- Oakes, Jonathan;
- Adams, Mary;
- Hurley, Christine;
- Dunaway, Shelia;
- Storey, Sheryl S;
- Van Dam, Cornelius;
- Epperson, Kim;
- Tebas, Pablo;
- Thomas, Aleshia;
- Klevens, Lisa;
- Mattiucci, Sara;
- Walton, Trisha;
- Baum, Jane;
- Spitz, Teresa;
- DeMarco, Debra;
- Sha, Beverly E;
- Green, Tondria;
- Basler, Cathi;
- Griesmer, Christine;
- Aberg, Judith A;
- Cespedes, Michelle S;
- Valle, Sandra;
- Slamowitz, Debbie;
- Currier, Judith;
- Cajahuaringa, Vanessa;
- Taiwo, Babafemi;
- McGregor, Donna;
- Kumar, Princy;
- Timpone, Joseph;
- Albrecht, Mary;
- Kershaw, Andrea;
- Sax, Paul;
- Keenan, Cheryl;
- Daar, Eric;
- Lopez, Ruben;
- Luetkemeyer, Annie;
- Dwyer, Jay;
- Ellner, Jerrold;
- Linas, Benjamin;
- Hughes, Valery;
- Lopez-Detres, Luis;
- Davis, Traci;
- Whitely, Kim;
- Palmore, Melody;
- Gunthel, Clifford
- et al.
Published Web Location
https://doi.org/10.1093/infdis/jiv433Abstract
Unlabelled
We measured plasma human immunodeficiency virus type 1 (HIV-1) RNA levels by means of single-copy assay in 334 participants receiving virologically suppressive antiretroviral therapy (ART). A residual viremia load of ≥1 copy/mL after 4 years of ART was predicted by a higher pre-ART HIV-1 RNA level, higher CD8(+) T-cell count during treatment, and a lower ratio of CD4+ T cells to CD8+ T cells during treatment but not by initial ART regimen. In a longitudinal subset of 64 individuals, continued decay of the plasma HIV-1 RNA level was observed, with an average annual decrease of 6% and an estimated half-life of 11.5 years. In contrast to prior reports, the persistent viremia level continues to slowly decline during years 4-12 of suppressive ART.Clinical trials registration
NCT00001137.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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