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Functionalized Methionine Polypeptides And Their Self Assembly

  • Author(s): Higgins, Robin
  • Advisor(s): Deming, Timothy J
  • et al.
Abstract

The synthesis and modification of polypeptides from NCAs is described. Diblocks containing a hydrophilic segment of poly(Met) and a hydrophobic segment of rac-Leu were self-assembled into micelles. The poly(Met) was either oxidized to the sulfoxide or alkylated to the carboxymethylated sulfonium.

Additionally, a diblock containing poly(Met) and PEG was synthesized. The poly(Met) segment was alkylated with bromo methyl boronic acid, and the polymers bound covalently and reversibly to compounds that contain diol groups.

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