Skip to main content
Open Access Publications from the University of California


UCLA Electronic Theses and Dissertations bannerUCLA

Functionalized Methionine Polypeptides And Their Self Assembly

  • Author(s): Higgins, Robin
  • Advisor(s): Deming, Timothy J
  • et al.

The synthesis and modification of polypeptides from NCAs is described. Diblocks containing a hydrophilic segment of poly(Met) and a hydrophobic segment of rac-Leu were self-assembled into micelles. The poly(Met) was either oxidized to the sulfoxide or alkylated to the carboxymethylated sulfonium.

Additionally, a diblock containing poly(Met) and PEG was synthesized. The poly(Met) segment was alkylated with bromo methyl boronic acid, and the polymers bound covalently and reversibly to compounds that contain diol groups.

Main Content
Current View