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A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.

  • Author(s): Petersen, Gloria M
  • Amundadottir, Laufey
  • Fuchs, Charles S
  • Kraft, Peter
  • Stolzenberg-Solomon, Rachael Z
  • Jacobs, Kevin B
  • Arslan, Alan A
  • Bueno-de-Mesquita, H Bas
  • Gallinger, Steven
  • Gross, Myron
  • Helzlsouer, Kathy
  • Holly, Elizabeth A
  • Jacobs, Eric J
  • Klein, Alison P
  • LaCroix, Andrea
  • Li, Donghui
  • Mandelson, Margaret T
  • Olson, Sara H
  • Risch, Harvey A
  • Zheng, Wei
  • Albanes, Demetrius
  • Bamlet, William R
  • Berg, Christine D
  • Boutron-Ruault, Marie-Christine
  • Buring, Julie E
  • Bracci, Paige M
  • Canzian, Federico
  • Clipp, Sandra
  • Cotterchio, Michelle
  • de Andrade, Mariza
  • Duell, Eric J
  • Gaziano, J Michael
  • Giovannucci, Edward L
  • Goggins, Michael
  • Hallmans, Göran
  • Hankinson, Susan E
  • Hassan, Manal
  • Howard, Barbara
  • Hunter, David J
  • Hutchinson, Amy
  • Jenab, Mazda
  • Kaaks, Rudolf
  • Kooperberg, Charles
  • Krogh, Vittorio
  • Kurtz, Robert C
  • Lynch, Shannon M
  • McWilliams, Robert R
  • Mendelsohn, Julie B
  • Michaud, Dominique S
  • Parikh, Hemang
  • Patel, Alpa V
  • Peeters, Petra HM
  • Rajkovic, Aleksandar
  • Riboli, Elio
  • Rodriguez, Laudina
  • Seminara, Daniela
  • Shu, Xiao-Ou
  • Thomas, Gilles
  • Tjønneland, Anne
  • Tobias, Geoffrey S
  • Trichopoulos, Dimitrios
  • Van Den Eeden, Stephen K
  • Virtamo, Jarmo
  • Wactawski-Wende, Jean
  • Wang, Zhaoming
  • Wolpin, Brian M
  • Yu, Herbert
  • Yu, Kai
  • Zeleniuch-Jacquotte, Anne
  • Fraumeni, Joseph F
  • Hoover, Robert N
  • Hartge, Patricia
  • Chanock, Stephen J
  • et al.

Published Web Location

http://10.0.4.14/ng.522
No data is associated with this publication.
Abstract

We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.

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