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SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK

  • Author(s): Nakamura, Ken
  • Verdin, Eric
  • Ho, L
  • Titus, AS
  • Banerjee, KK
  • George, S
  • Lin, W
  • Deota, S
  • Saha, AK
  • Gut, P
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3868726?pdf=render
No data is associated with this publication.
Abstract

Efficient coupling of cellular energy production to metabolic demand is crucial to maintain organismal homeostasis. Here, we report that the mitochondrial Sirtuin Sirt4 regulates mitochondrial ATP homeostasis. We find that Sirt4 affects mitochondrial uncou

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