Synthesis and duplex-stabilizing properties of fluorinated n-methanocarbothymidine analogues locked in the C3'-endo conformation
- Author(s): Jung, ME
- Dwight, TA
- Vigant, F
- Østergaard, ME
- Swayze, EE
- Seth, PP
- et al.
Published Web Locationhttps://doi.org/10.1002/anie.201405283
The efficient synthesis, antiviral activity, and duplex-stabilizing properties of both isomers of the 2'-fluoro analogue of Northern methanocarbathymidine (N-MCT), 2 and 3, are reported. We show that 2'-F incorporation on the N-MCT scaffold has a strong stabilizing effect on duplex thermal stability. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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