Skip to main content
eScholarship
Open Access Publications from the University of California

The road less traveled: Regulation of leukocyte migration across vascular and lymphatic endothelium by galectins

  • Author(s): Thiemann, S
  • Baum, LG
  • et al.

Published Web Location

http://link.springer.com/article/10.1007/s10875-010-9460-z/fulltext.html
No data is associated with this publication.
Abstract

Leukocyte entry from the blood into inflamed tissues, exit into the lymphatics, and migration to regional lymph nodes are all crucial processes for mounting an effective adaptive immune response. Leukocytes must cross two endothelial cell layers, the vascular and the lymphatic endothelial cell layers, during the journey from the blood to the lymph node. The proteins and cellular interactions which regulate leukocyte migration across the vascular endothelium are well studied; however, little is known about the factors that regulate leukocyte migration across the lymphatic endothelium. Here, we will summarize evidence for a role for galectins, a family of carbohydrate-binding proteins, in regulating leukocyte migration across the vascular endothelium and propose that galectins are also involved in leukocyte migration across the lymphatic endothelium. © 2010 The Author(s).

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item