Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration
- Author(s): Oveisi, F
- Gaetani, S
- Eng, KTP
- Piomelli, D
- et al.
Published Web Locationhttps://doi.org/10.1016/j.phrs.2003.12.006
Oleoylethanolamide (OEA) is an endogenous lipid that contributes in important ways to the peripheral regulation of food intake. When administered intraperitoneally, OEA is a potent satiety-inducing anorexiant in rats and mice [Nature 414 (2001) 209; Neuropsycopharmacology 28 (2003) 1311; Nature 425 (2003) 90]. In the present study, we show that oral administration of OEA in pH-sensitive enteric-coated capsules produces a profound and long-lasting inhibition of food intake in free-feeding rats. This effect is accompanied by a marked elevation in OEA levels in the small intestine, but not in brain or muscle. © 2004 Elsevier Ltd. All rights reserved.
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