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Open Access Publications from the University of California

Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration

  • Author(s): Oveisi, F
  • Gaetani, S
  • Eng, KTP
  • Piomelli, D
  • et al.

Oleoylethanolamide (OEA) is an endogenous lipid that contributes in important ways to the peripheral regulation of food intake. When administered intraperitoneally, OEA is a potent satiety-inducing anorexiant in rats and mice [Nature 414 (2001) 209; Neuropsycopharmacology 28 (2003) 1311; Nature 425 (2003) 90]. In the present study, we show that oral administration of OEA in pH-sensitive enteric-coated capsules produces a profound and long-lasting inhibition of food intake in free-feeding rats. This effect is accompanied by a marked elevation in OEA levels in the small intestine, but not in brain or muscle. © 2004 Elsevier Ltd. All rights reserved.

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