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Comparative epigenomics: defining and utilizing epigenomic variations across species, time-course, and individuals.
Published Web Locationhttp://www.sciencedirect.com/science/article/pii/S0092867412005740
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UnlabelledEpigenomic profiling, by revealing genome-wide distributions of epigenetic modifications, generated a large amount of structural information about the chromosomes. Epigenomic analysis has quickly become a big data science, posing tremendous challenges on its translation into knowledge. To meet this challenge, comparative analysis of epigenomes, dubbed comparative epigenomics, has emerged as an active research area. Here, we summarize the recent developments in comparative epigenomic analyses into three major directions, namely the comparisons across species, the time-course of a biological process, and individuals. We review the main ideas, methods, and findings in each direction, and discuss the implications to understanding the regulatory functions of the genomes.
Conflict of interestThe authors have declared no conflicts of interest for this article.
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