Skip to main content
eScholarship
Open Access Publications from the University of California

Comparative epigenomics: Defining and utilizing epigenomic variations across species, time-course, and individuals

  • Author(s): Xiao, S
  • Cao, X
  • Zhong, S
  • et al.

Published Web Location

http://www.sciencedirect.com/science/article/pii/S0092867412005740
No data is associated with this publication.
Abstract

Epigenomic profiling, by revealing genome-wide distributions of epigenetic modifications, generated a large amount of structural information about the chromosomes. Epigenomic analysis has quickly become a big data science, posing tremendous challenges on its translation into knowledge. To meet this challenge, comparative analysis of epigenomes, dubbed comparative epigenomics, has emerged as an active research area. Here, we summarize the recent developments in comparative epigenomic analyses into three major directions, namely the comparisons across species, the time-course of a biological process, and individuals. We review the main ideas, methods, and findings in each direction, and discuss the implications to understanding the regulatory functions of the genomes. © 2014 Wiley Periodicals, Inc.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item