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Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat.
- Author(s): Nyein, Hnin Yin Yin;
- Bariya, Mallika;
- Kivimäki, Liisa;
- Uusitalo, Sanna;
- Liaw, Tiffany Sun;
- Jansson, Elina;
- Ahn, Christine Heera;
- Hangasky, John A;
- Zhao, Jiangqi;
- Lin, Yuanjing;
- Happonen, Tuomas;
- Chao, Minghan;
- Liedert, Christina;
- Zhao, Yingbo;
- Tai, Li-Chia;
- Hiltunen, Jussi;
- Javey, Ali
- et al.
Published Web Location
https://doi.org/10.1126/sciadv.aaw9906Abstract
Recent technological advancements in wearable sensors have made it easier to detect sweat components, but our limited understanding of sweat restricts its application. A critical bottleneck for temporal and regional sweat analysis is achieving uniform, high-throughput fabrication of sweat sensor components, including microfluidic chip and sensing electrodes. To overcome this challenge, we introduce microfluidic sensing patches mass fabricated via roll-to-roll (R2R) processes. The patch allows sweat capture within a spiral microfluidic for real-time measurement of sweat parameters including [Na+], [K+], [glucose], and sweat rate in exercise and chemically induced sweat. The patch is demonstrated for investigating regional sweat composition, predicting whole-body fluid/electrolyte loss during exercise, uncovering relationships between sweat metrics, and tracking glucose dynamics to explore sweat-to-blood correlations in healthy and diabetic individuals. By enabling a comprehensive sweat analysis, the presented device is a crucial tool for advancing sweat testing beyond the research stage for point-of-care medical and athletic applications.
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