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Open Access Publications from the University of California

Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat.

  • Author(s): Nyein, Hnin Yin Yin;
  • Bariya, Mallika;
  • Kivimäki, Liisa;
  • Uusitalo, Sanna;
  • Liaw, Tiffany Sun;
  • Jansson, Elina;
  • Ahn, Christine Heera;
  • Hangasky, John A;
  • Zhao, Jiangqi;
  • Lin, Yuanjing;
  • Happonen, Tuomas;
  • Chao, Minghan;
  • Liedert, Christina;
  • Zhao, Yingbo;
  • Tai, Li-Chia;
  • Hiltunen, Jussi;
  • Javey, Ali
  • et al.

Recent technological advancements in wearable sensors have made it easier to detect sweat components, but our limited understanding of sweat restricts its application. A critical bottleneck for temporal and regional sweat analysis is achieving uniform, high-throughput fabrication of sweat sensor components, including microfluidic chip and sensing electrodes. To overcome this challenge, we introduce microfluidic sensing patches mass fabricated via roll-to-roll (R2R) processes. The patch allows sweat capture within a spiral microfluidic for real-time measurement of sweat parameters including [Na+], [K+], [glucose], and sweat rate in exercise and chemically induced sweat. The patch is demonstrated for investigating regional sweat composition, predicting whole-body fluid/electrolyte loss during exercise, uncovering relationships between sweat metrics, and tracking glucose dynamics to explore sweat-to-blood correlations in healthy and diabetic individuals. By enabling a comprehensive sweat analysis, the presented device is a crucial tool for advancing sweat testing beyond the research stage for point-of-care medical and athletic applications.

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