Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery
- Author(s): Renslo, Adam
- Fontaine, SD
- DiPasquale, AG
- Renslo, AR
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4227544?pdf=render
© 2014 American Chemical Society.Ferrous iron-promoted reduction of a hindered peroxide bond underlies the antimalarial action of the 1,2,4-trioxane artemisinin and the 1,2,4-trioxolane arterolane. In appropriately designed systems, a 1,2,4-trioxolane ring