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Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery

  • Author(s): Renslo, Adam
  • Fontaine, SD
  • DiPasquale, AG
  • Renslo, AR
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4227544?pdf=render
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Abstract

© 2014 American Chemical Society.Ferrous iron-promoted reduction of a hindered peroxide bond underlies the antimalarial action of the 1,2,4-trioxane artemisinin and the 1,2,4-trioxolane arterolane. In appropriately designed systems, a 1,2,4-trioxolane ring

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