Coevolutionary analyses require phylogenetically deep alignments and better null models to accurately detect inter-protein contacts within and between species
- Author(s): Pollard, Katherine;
- Avila-Herrera, A;
- Pollard, KS
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4549020?pdf=render
© 2015 Avila-Herrera and Pollard. Background: When biomolecules physically interact, natural selection operates on them jointly. Contacting positions in protein and RNA structures exhibit correlated patterns of sequence evolution due to constraints imposed