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Coevolutionary analyses require phylogenetically deep alignments and better null models to accurately detect inter-protein contacts within and between species

  • Author(s): Pollard, Katherine
  • Avila-Herrera, A
  • Pollard, KS
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4549020?pdf=render
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Abstract

© 2015 Avila-Herrera and Pollard. Background: When biomolecules physically interact, natural selection operates on them jointly. Contacting positions in protein and RNA structures exhibit correlated patterns of sequence evolution due to constraints imposed

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