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Ligand Synthesis for Hepatitis C Virus Internal Ribosome Entry Site


Benzothiadiazines were synthesized and tested for their binding affinity with hepatitis C virus internal ribosome entry site subdomain IIa using FRET assay. The acetylated compound was designed to improve the solubility and explore the tautomerization involved in targeting the IIa subdomain. An optimized Cu2O catalyzed Ullmann reaction was developed for future use.

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