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Open Access Publications from the University of California

A toxic epidermal necrolysis-like presentation of linear IgA bullous dermatosis treated with dapsone

  • Author(s): Nguyen, Julie K
  • Koshelev, Misha V
  • Gill, Bartley J
  • Boulavsky, Jessica
  • Diwan, Abdul Hafeez
  • Dao Jr, Harry
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license

Linear IgA bullous dermatosis is a rare autoimmune vesiculobullous disease characterized by linear deposition of IgA along the basement membrane zone. It is classically idiopathic, but may also arise secondary to drug exposure. A heterogeneous spectrum of clinical features has been described, including a rare, morbid variant mimicking toxic epidermal necrolysis. Herein, we present a case of vancomycin-induced linear IgA bullous dermatosis that manifested clinically as toxic epidermal necrolysis and resolved with dapsone therapy.

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