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Central Visual Field Defects in Patients with Distinct Glaucomatous Optic Disc Phenotypes.
- Author(s): Ekici, Eren;
- Moghimi, Sasan;
- Hou, Huiyuan;
- Proudfoot, James;
- Zangwill, Linda M;
- Do, Jiun L;
- Oh, Won Hyuk;
- Kamalipour, Alireza;
- Liebmann, Jeffrey M;
- De Moraes, Carlos Gustavo;
- Girkin, Christopher A;
- El-Nimri, Nevin;
- Weinreb, Robert N
- et al.
Published Web Locationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979468/
No data is associated with this publication.
PurposeTo investigate central visual field (VF) defects among 4 phenotypes of glaucomatous optic discs.
MethodsOptic disc phenotypes were determined in eyes with definite or suspected glaucoma that had a 24-2 VF with mean deviation (MD) better than -12 dB and a 10-2 VF. 10-2 VFs were classified as abnormal based on a cluster criterion. Additionally, the average of the total deviation values at each 10-2 test point was compared by optic disc phenotype.
ResultsThe following 4 glaucomatous optic disc phenotypes were identified in 448 eyes of 309 patients: focal ischemic (FI) (n = 121); generalized cup enlargement (GE) (n = 109); myopic glaucoma (MY) (n = 66); and senile sclerotic (SS) (n = 152). Although 24-2 VF MD values were similar among optic disc phenotypes, GE eyes had higher 10-2 VF MD (P = .004), as well as lower 24-2 VF pattern standard deviations (PSD) (P < .001) and VF 10-2 PSD (P < .001) than the other phenotypes. The prevalence of an abnormal VF 10-2 was highest in FI eyes (78.5%) and lowest in GE eyes (50.5%) (P < .001). In glaucoma suspects, the prevalence of an abnormal 10-2 VF was highest in the MY eyes (31.2%) and FI eyes (23.5%) and lowest in GE eyes (8.6%). In mild glaucoma, the prevalence of abnormal 10-2 VF test results was highest in FI eyes (79.2%) and lowest in GE eyes (44.4%) (P = .013).
ConclusionsThe severity and prevalence of central VF loss varied among different glaucomatous optic disc phenotypes. Glaucomatous eyes with FI and MY optic disc phenotypes are more likely to have 10-2 VF loss, particularly in early disease, and especially may benefit from testing with both 10-2 and 24-2 VF tests.
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