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Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways
- Shih, Vincent F-S;
- Davis-Turak, Jeremy;
- Macal, Monica;
- Huang, Jenny Q;
- Ponomarenko, Julia;
- Kearns, Jeffrey D;
- Yu, Tony;
- Fagerlund, Riku;
- Asagiri, Masataka;
- Zuniga, Elina I;
- Hoffmann, Alexander
Published Web Location
https://doi.org/10.1038/ni.2446Abstract
Noncanonical RelB–NF-κB2 heterodimers function in homeostatic signaling. Hoffmann and colleagues show that RelB-p50 complexes, regulated by IκB, exist in dendritic cells and contribute to inflammatory gene expression via canonical NF-κB pathway activation.
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