The Type III Secretion System Cleans up Its Act(in).
Published Web Locationhttps://doi.org/10.1016/j.chom.2016.08.012
Inflammasome-associated innate immune receptors sense host-cell targeting by the type III secretion system (T3SS) of pathogenic Yersinia. In this issue of Cell Host & Microbe, Chung et al. (2016) show that the Yersinia T3SS effector protein YopM counteracts this recognition pathway by restricting the pyrin inflammasome, thus increasing bacterial fitness.